Lavreysen, H.: search on Z-Library

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1

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Andrés, José-Ignacio, Alcázar, Jesús, Cid, José María, De Angelis, Meri, Iturrino, Laura, Langlois, Xavier, Lavreysen, Hilde, Trabanco, Andrés A., Celen, Sofie, Bormans, Guy

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 561 KB

english, 2012

2

Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold

Rodriguez, Alice L., Zhou, Ya, Williams, Richard, David Weaver, C., Vinson, Paige N., Dawson, Eric S., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M., Macdonald, Gregor J., Sco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

3

Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover

Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.57 MB

english, 2012

4

Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782

Lavreysen, H., Langlois, X., Ahnaou, A., Drinkenburg, W., te Riele, P., Biesmans, I., Van der Linden, I., Peeters, L., Megens, A., Wintmolders, C., Cid, J. M., Trabanco, A. A., Andres, J. I., Dautzenb

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.62 MB

english, 2013

5

A covalent allosteric probe for the metabotropic glutamate receptor 2: Design, synthesis and pharmacological characterization

Doornbos, Maarten L.J., Wang, Xuesong, Vermond, Sophie C., Peeters, Luc, Pérez-Benito, Laura, Trabanco, Andrés A., Lavreysen, Hilde, Cid, José María, Heitman, Laura H., Tresadern, Gary, IJzerman, Adri

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.19 MB

english, 2018

6

Constitutive activity of the metabotropic glutamate receptor 2 explored with a whole-cell label-free biosensor

Doornbos, Maarten L.J., Van der Linden, Ilse, Vereyken, Liesbeth, Tresadern, Gary, IJzerman, Adriaan P., Lavreysen, Hilde, Heitman, Laura H.

Journal:

Biochemical Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.52 MB

english, 2018

7

Antagonist-induced supersensitivity of mGlu1 receptor signalling in cerebellar granule cells

Hilde Lavreysen, Tineke Willemoens, Joseé E. Leysen, Anne S. J. Lesage

Journal:

European Journal of Neuroscience

Year:

2005

Language:

english

File:

PDF, 285 KB

english, 2005

8

Therapeutic Potential of Group III Metabotropic Glutamate Receptors

Lavreysen, Hilde, Dautzenberg, Frank

Journal:

Current Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 355 KB

english, 2008

9

Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test

Thomas Steckler, Hilde Lavreysen, Ana M. Oliveira, Nancy Aerts, Hansfried Van Craenendonck, Jos Prickaerts, Anton Megens, Anne S. J. Lesage

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 278 KB

english, 2005

10

P.1.c.015 Differential effects of acute and sub-chronic PCP in rodent cognition: reversal with a selective mGlu2 negative allosteric modulator RO4491533

S. Embrechts, H. Lavreysen, L. Ver Donck, D.J. Pemberton

Journal:

European Neuropsychopharmacology

Year:

2012

Language:

english

File:

PDF, 63 KB

english, 2012

11

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia

Conde-Ceide, Susana, Alcázar, Jesús, Alonso de Diego, Sergio A., López, Silvia, Martín-Martín, María Luz, Martínez-Viturro, Carlos M., Pena, Miguel-Angel, Tong, Han Min, Lavreysen, Hilde, Mackie, Clai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 655 KB

english, 2015

12

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

Blobaum, A. L., Bridges, T. M., Byers, F. W., Turlington, M. L., Mattmann, M. E., Morrison, R. D., Mackie, C., Lavreysen, H., Bartolome, J. M., MacDonald, G. J., Steckler, T., Jones, C. K., Niswender,

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 370 KB

english, 2013

13

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Andrés A. Trabanco, Guillaume Duvey, José María Cid, Gregor J. Macdonald, Philippe Cluzeau, Vanthea Nhem, Rocco Furnari, Nadia Behaj, Géraldine Poulain, Terry Finn, Hilde Lavreysen, Sonia Poli, Alexan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

14

Pharmacology of JNJ-37822681, a Specific and Fast-Dissociating D2 Antagonist for the Treatment of Schizophrenia

Langlois, X., Megens, A., Lavreysen, H., Atack, J., Cik, M., te Riele, P., Peeters, L., Wouters, R., Vermeire, J., Hendrickx, H., Macdonald, G., De Bruyn, M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2012

Language:

english

File:

PDF, 611 KB

english, 2012

15

Generation of polyclonal antibodies directed against G protein-coupled receptors using electroporation-aided DNA immunization

Suzanne J.F. Kaptein, Joanne Jungscheleger-Russell, Pilar Martínez-Martínez, Patrick S. Beisser, Hilde Lavreysen, Annelies Vanheel, Mark H. De Baets, Cathrien A. Bruggeman, Cornelis Vink, Mario Losen

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 388 KB

english, 2008

16

Spiro-oxindole piperidines and 3-(azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 receptor PAMs

de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnación, Linares, María Lourdes, García Molina, Aránzazu, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andrés A., Cid, José María

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 317 KB

english, 2019

17

Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound

Zhou, Ya, Malosh, Chrysa, Conde-Ceide, Susana, Martínez-Viturro, Carlos Manuel, Alcázar, Jesus, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.56 MB

english, 2015

18

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

Turlington, Mark, Noetzel, Meredith J., Bridges, Thomas M., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Tong, Han Min, Macdon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 995 KB

english, 2014

19

mGlu2 receptor-mediated modulation of conditioned avoidance behavior in rats

Megens, Anton A.H.P., Hendrickx, Herman M.R., Hens, Koen A., Talloen, Willem J.-P.E., Lavreysen, Hilde

Journal:

European Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 666 KB

english, 2014

20

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 978 KB

english, 2015

21

P.3.d.009 Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia

X. Langlois, A. Megens, H. Lavreysen, R. Wouters, L. Peeters, P. te Riele, H. Hendrickx, M. Mahieu, M. de Bruyn, G. Macdonald

Journal:

European Neuropsychopharmacology

Year:

2010

Language:

english

File:

PDF, 45 KB

english, 2010

22

Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Martín-Martín, María Luz, Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Alonso de Diego, Sergio A., López, Silvia, Martínez-Viturro, Carlos M., Tong, Han Min, Lavreysen, Hilde, Macdonald, Grego

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 5.50 MB

english, 2015

23

Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

A. Trabanco, A., M. Cid, J., Lavreysen, H., J. Macdonald, G., Tresadern, G.

Journal:

Current Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 650 KB

english, 2011

24

Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor

Pérez-Benito, Laura, Doornbos, Maarten L.J., Cordomí, Arnau, Peeters, Luc, Lavreysen, Hilde, Pardo, Leonardo, Tresadern, Gary

Journal:

Year:

2017

Language:

english

File:

PDF, 2.87 MB

english, 2017

25

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Gary Tresadern, Jose María Cid, Gregor J. Macdonald, Juan Antonio Vega, Ana Isabel de Lucas, Aránzazu García, Encarnación Matesanz, María Lourdes Linares, Daniel Oehlrich, Hilde Lavreysen, Ilse Biesma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.57 MB

english, 2010

26

Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127

Hilde Lavreysen, Sandrina Nóbrega Pereira, Joseé E Leysen, Xavier Langlois, Anne S.J Lesage

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 1.20 MB

english, 2004

27

Erratum

Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M.,

Journal:

Nutrition Research

Year:

1993

File:

PDF, 18 KB

1993

28

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu 5 )

Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T., Noetzel, Meredith J., Vinson, Paige N., Jadhav, Satyawan, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, Jos

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.86 MB

english, 2014

29

Characterization of JNJ-1930942, a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor

Anne Lesage, Theo Dinklo, Jan-Willem Thuring, Christopher Grantham, Luc Peeters, Hilde Lavreysen, Hamdy Shaban, Karen E. Stevens, Lijun Zheng

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 60 KB

english, 2009

30

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2

Farinha, A, Lavreysen, H, Peeters, L, Russo, B, Masure, S, Trabanco, A A, Cid, J, Tresadern, G

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

31

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222

Doornbos, Maarten L J, Pérez-Benito, Laura, Tresadern, Gary, Mulder-Krieger, Thea, Biesmans, Ilse, Trabanco, Andrés A, Cid, Jose María, Lavreysen, Hilde, IJzerman, Adriaan P, Heitman, Laura H

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.52 MB

english, 2016

32

Differential Interaction of Neuroleptics with Apomorphine-Induced Behavior in Rats as a Function of Changing Levels of Dopamine Receptor Stimulation

Megens, A. A. H. P., Hendrickx, H. M. R., Lavreysen, H., Langlois, X.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 2.20 MB

english, 2013

33

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

Noetzel, M. J., Rook, J. M., Vinson, P. N., Cho, H. P., Days, E., Zhou, Y., Rodriguez, A. L., Lavreysen, H., Stauffer, S. R., Niswender, C. M., Xiang, Z., Daniels, J. S., Jones, C. K., Lindsley, C. W.

Journal:

Molecular Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

34

Discovery of VU0409551/JNJ-46778212: An mGlu 5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 973 KB

english, 2015

35

321. Watching Synapses in Action: From Assaying Synaptic Function to Drug Discovery

Kashikar, Nachiket, Kemp, John, Lavreysen, Hilde

Journal:

Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 41 KB

english, 2017

36

10.1124/jpet.110.173245

Dinklo, T., Shaban, H., Thuring, J. W., Lavreysen, H., Stevens, K. E., Zheng, L., Mackie, C., Grantham, C., Vandenberk, I., Meulders, G.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2011

Language:

english

File:

PDF, 786 KB

english, 2011

37

Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813

Lavreysen, Hilde, Langlois, Xavier, Donck, Luc Ver, Nuñez, José María Cid, Pype, Stefan, Lütjens, Robert, Megens, Anton

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 623 KB

english, 2015

38

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model

Metcalf, Cameron S., Klein, Brian D., Smith, Misty D., Ceusters, Marc, Lavreysen, Hilde, Pype, Stefan, Van Osselaer, Nancy, Twyman, Roy, White, H. Steve

Journal:

Year:

2018

Language:

english

File:

PDF, 877 KB

english, 2018

39

[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists

Journal:

Molecular Pharmacology

Year:

2003

Language:

english

File:

PDF, 303 KB

english, 2003

40

Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor

Cid, José María, Lavreysen, Hilde, Tresadern, Gary, Pérez-Benito, Laura, Tovar, Fulgencio, Fontana, Alberto, Trabanco, Andrés A.

Journal:

ACS Chemical Neuroscience

Year:

2018

Language:

english

File:

PDF, 682 KB

english, 2018

41

In the grey zone between epilepsy and schizophrenia: alterations in group II metabotropic glutamate receptors

Dedeurwaerdere, Stefanie, Boets, Stephanie, Janssens, Pieter, Lavreysen, Hilde, Steckler, Thomas

Journal:

Acta Neurologica Belgica

Year:

2015

Language:

english

File:

PDF, 854 KB

english, 2015

42

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor

Lavreysen, Hilde, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Langlois, Xavier, Mackie, Claire, Pype, Stefan, Lütjens, Robert, Le Poul, Emmanuel, Trabanco, Andrés A., Nuñez, José María Cid

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 840 KB

english, 2015

43

Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men

Ahnaou, A., de Boer, P., Lavreysen, H., Huysmans, H., Sinha, V., Raeymaekers, L., Van De Casteele, T., Cid, J.M., Van Nueten, L., Macdonald, G.J., Kemp, J.A., Drinkenburg, W.H.I.M.

Journal:

Neuropharmacology

Year:

2016

Language:

english

File:

PDF, 2.17 MB

english, 2016

44

Efficacy of mGlu 2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

Metcalf, Cameron S., Klein, Brian D., Smith, Misty D., Pruess, Tim, Ceusters, Marc, Lavreysen, Hilde, Pype, Stefan, Van Osselaer, Nancy, Twyman, Roy, White, H. Steve

Journal:

Year:

2017

Language:

english

File:

PDF, 402 KB

english, 2017

45

Impact of allosteric modulation: Exploring the binding kinetics of glutamate and other orthosteric ligands of the metabotropic glutamate receptor 2

Doornbos, Maarten L.J., Vermond, Sophie C., Lavreysen, Hilde, Tresadern, Gary, IJzerman, Adriaan P., Heitman, Laura H.

Journal:

Biochemical Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.70 MB

english, 2018

46

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist

Hilde Lavreysen, Ria Wouters, François Bischoff, Sandrina Nóbrega Pereira, Xavier Langlois, Saskia Blokland, Marijke Somers, Lieve Dillen, Anne S.J. Lesage

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 314 KB

english, 2004

47

Supersensitivity of Human Metabotropic Glutamate 1a Receptor Signaling in L929sA Cells

Journal:

Molecular Pharmacology

Year:

2002

Language:

english

File:

PDF, 285 KB

english, 2002

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